Effect of ibandronate on bending strength and toughness of rodent cortical bone
نویسندگان
چکیده
Bone Joint Res 2015;4:99–104. Received 28 March 2014; Accepted after revision 01 April 2015 Objectives There remains conflicting evidence regarding cortical bone strength following bisphosphonate therapy. As part of a study to assess the effects of bisphosphonate treatment on the healing of rat tibial fractures, the mechanical properties and radiological density of the uninjured contralateral tibia was assessed.
منابع مشابه
Effect of ibandronate on bending strength and toughness of rodent cortical bone: Possible implications for fracture prevention.
OBJECTIVES There remains conflicting evidence regarding cortical bone strength following bisphosphonate therapy. As part of a study to assess the effects of bisphosphonate treatment on the healing of rat tibial fractures, the mechanical properties and radiological density of the uninjured contralateral tibia was assessed. METHODS Skeletally mature aged rats were used. A total of 14 rats recei...
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We report the results of a series of experiments designed to determine the effects of ibandronate (Ibn) and risedronate (Ris) on a number of bone quality parameters in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti-fracture efficacy. Eighteen-month old female rats underwent either ovariectomy or sh...
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